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Intradiscal Leukocyte Rich Platelet Rich Plasma for Degenerative Disc Disease

Published:October 17, 2022DOI:https://doi.org/10.1016/j.pmr.2022.08.009

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      References

        • GBD 2017 Disease and Injury Incidence and Prevalence Collaborators
        Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.
        Lancet. 2018; 392: 1789-1858
        • Donelson R.
        • McIntosh G.
        • Hall H.
        Is it time to rethink the typical course of low back pain?.
        PM R. 2012; 4 (Epub 2012 Mar 3. PMID: 22381638): 394-401
        • Deyo R.A.
        • Von Korff M.
        • Duhrkoop D.
        Opioids for low back pain.
        BMJ. 2015; 350 (PMID: 25561513; PMCID: PMC6882374): g6380
      1. Scholl L, Seth P, Kariisa M, et al. Drug and Opioid-Involved Overdose Deaths - United States, 2013-2017, MMWR Morb Mortal Wkly Rep, 67(5152);2018:1419-1427.

        • Centers for Disease Control and Prevention
        2018 annual surveillance report of drug-related risks and outcomes — United States. Surveillance special report 2 pdf icon centers for disease control and prevention.
        U.S. Department of Health and Human Services, Washington, DC2018
        • GBD 2019 Diseases
        • Injuries Collaborators
        Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.
        Lancet (London, England). 2020; 396: 1204-1222
        • Lo Y.T.
        • Lim-Watson M.
        • Seo Y.
        • et al.
        Long-Term Opioid Prescriptions After Spine Surgery: A Meta-Analysis of Prevalence and Risk Factors.
        World Neurosurg. 2020; 141: e894-e920
        • Deng H.
        • Yue J.K.
        • Ordaz A.
        • et al.
        Elective lumbar fusion in the United States: national trends in inpatient complications and cost from 2002-2014.
        J Neurosurg Sci. 2021; 65: 503-512
        • Institute of Medicine of the National Academy of Science
        Relieving pain in America: a blueprint for transforming prevention, care, Jamesucation, and research.
        Institute of Medicine, Washington, DC, USA2011: 5
        • Dieleman J.L.
        • Cao J.
        • Chapin A.
        • et al.
        US health care spending by payer and health condition, 1996-2016.
        JAMA. 2020; 323: 863-884
        • Gilligan C.J.
        • Cohen S.P.
        • Fischetti V.A.
        • et al.
        Chronic low back pain, bacterial infection and treatment with antibiotics.
        Spine J. 2021; 21 (Epub 2021 Feb 19. PMID: 33610802): 903-914
        • Grunhagen T.
        • Wilde G.
        • Soukane D.M.
        • et al.
        Nutrient supply and intervertebral disc metabolism.
        J Bone Joint Surg Am. 2006; 88 (PMID: 16595440): 30-35
        • Kirkaldy-Willis W.H.
        • Wedge J.H.
        • Yong-Hing K.
        • et al.
        Pathology and pathogenesis of lumbar spondylosis and stenosis.
        Spine (Phila Pa 1976). 1978; 3 (PMID: 741238): 319-328
        • Kho Z.Y.
        • Lal S.K.
        The human gut microbiome—a potential controller of wellness and disease.
        Front Microbiol. 2018; https://doi.org/10.3389/fmicb.2018.01835
        • Albert H.B.
        • Sorensen J.S.
        • Christensen B.S.
        • et al.
        Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized clinical controlled trial of efficacy.
        Eur Spine J. 2013; 22 (Epub 2013 Feb 13. PMID: 23404353; PMCID: PMC3631045): 697-707
        • Chen Z.
        • Zheng Y.
        • Yuan Y.
        • et al.
        Modic Changes and Disc Degeneration Caused by Inoculation of Propionibacterium acnes inside Intervertebral Discs of Rabbits: A Pilot Study.
        Biomed Res Int. 2016; 2016: 9612437
        • Akeda K.
        • An H.S.
        • Pichika R.
        • et al.
        Platelet-rich plasma (PRP) stimulates the extracellular matrix metabolism of porcine nucleus pulposus and annulus fibrosus cells cultured in alginate beads.
        Spine (Phila Pa 1976. 2006; 31: 959-966
        • Chen W.H.
        • Lo W.C.
        • Lee J.J.
        • et al.
        Tissue-engineered intervertebral disc and chondrogenesis using human nucleus pulposus regulated through TGF-beta1 in platelet-rich plasma.
        J Cell Physiol. 2006; 209: 744-754
        • Tuakli-Wosornu Y.A.
        • Terry A.
        • Boachie-Adjei K.
        • et al.
        Lumbar Intradiskal Platelet-Rich Plasma (PRP) Injections: A Prospective, Double-Blind, Randomized Controlled Study.
        PM R. 2016; 8 (Epub 2015 Aug 24. PMID: 26314234): 1-10
        • Monfett M.
        • Harrison J.
        • Boachie-Adjei K.
        • et al.
        Intradiscal platelet-rich plasma (PRP) injections for discogenic low back pain: an update.
        Int Orthop. 2016 Jun; 40 (Epub 2016 Apr 12. PMID: 27073034): 1321-1328
        • Cheng J.
        • Santiago K.A.
        • Nguyen J.T.
        • et al.
        Treatment of symptomatic degenerative intervertebral discs with autologous platelet-rich plasma: follow-up at 5-9 years.
        Regen Med. 2019; 14 (Epub 2019 Aug 29. PMID: 31464577; PMCID: PMC6770415): 831-840
        • Akeda K.
        • Yamada J.
        • Linn E.T.
        • et al.
        Platelet-Rich Plasma in the Management of Chronic Low Back Pain: A Critical Review.
        J Pain Res. 2019; 12: 753-767
        • Akeda K.
        • Takegami N.
        • Yamada J.
        • et al.
        Platelet-Rich Plasma-Releasate (PRPr) for the Treatment of Discogenic Low Back Pain Patients: Long-Term Follow-Up Survey.
        Medicina (Kaunas). 2022; 58 (PMCID: PMC8952290): 428
        • Akeda K.
        • Ohishi K.
        • Takegami N.
        • et al.
        Platelet-Rich Plasma Releasate versus Corticosteroid for the Treatment of Discogenic Low Back Pain: A Double-Blind Randomized Controlled Trial.
        J Clin Med. 2022; 11 (PMID: 35053999; PMCID: PMC8777786): 304
        • Prysak M.H.
        • Kyriakides C.P.
        • Zukofsky T.A.
        • et al.
        A retrospective analysis of a commercially available platelet-rich plasma kit during clinical use.
        PM R. 2021; 13 (Epub 2021 Apr 12. PMID: 33543595): 1410-1417
        • Lutz C.
        • Cheng J.
        • Prysak M.
        • et al.
        Clinical outcomes following intradiscal injections of higher-concentration platelet-rich plasma in patients with chronic lumbar discogenic pain.
        Int Orthop. 2022; (Epub ahead of print. PMID: 35344055)https://doi.org/10.1007/s00264-022-05389-y
        • Beatty N.R.
        • Lutz C.
        • Boachie-Adjei K.
        • et al.
        Spondylodiscitis due to Cutibacterium acnes following lumbosacral intradiscal biologic therapy: a case report.
        Regen Med. 2019; 14 (Epub 2019 Aug 19. PMID: 31423905): 823-829
        • Jerome M.A.
        • Lutz C.
        • Lutz G.E.
        Risks of Intradiscal Orthobiologic Injections: A Review of the Literature and Case Series Presentation.
        Int J Spine Surg. 2021; 15 (Apr 21. PMID: 34376494; PMCID: PMC8092939): 26-39
        • Prysak M.H.
        • Lutz C.G.
        • Zukofsky T.A.
        • et al.
        Optimizing the safety of intradiscal platelet-rich plasma: an in vitro study with Cutibacterium acnes.
        Regen Med. 2019; 14 (Epub 2019 Oct 7. PMID: 31587600): 955-967
        • Muthu S.
        • Jeyaraman M.
        • Chellamuthu G.
        • et al.
        Does the Intradiscal Injection of Platelet Rich Plasma Have Any Beneficial Role in the Management of Lumbar Disc Disease?.
        Glob Spine J. 2022; 12 (PMID: 33840260): 503-514