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An Evidence-Based Approach to Orthobiologics for Tendon Disorders

Published:October 17, 2022DOI:https://doi.org/10.1016/j.pmr.2022.08.007

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      References

        • Almekinders L.C.
        • Temple J.D.
        Etiology, diagnosis, and treatment of tendonitis: an analysis of the literature.
        Med Sci Sports Exerc. 1998; 30: 1183-1190
        • Wang J.H.-C.
        • Guo Q.
        • Li B.
        Tendon biomechanics and mechanobiology—a minireview of basic concepts and recent advancements.
        J Hand Ther. 2012; 25: 133-141
        • Jones G.C.
        • Corps A.N.
        • Pennington C.J.
        • et al.
        Expression profiling of metalloproteinases and tissue inhibitors of metalloproteinases in normal and degenerate human achilles tendon.
        Arthritis Rheum. 2006; 54: 832-842
        • Robinson P.
        Sonography of common tendon injuries.
        AJR Am J Roentgenol. 2009; 193: 607-618
        • Hartley D.R.
        • McMahon J.J.
        The role of strength training for lower extremity tendinopathy.
        Strength Conditioning J. 2018; 40: 85-95
        • Irby A.
        • Gutierrez J.
        • Chamberlin C.
        • et al.
        Clinical management of tendinopathy: a systematic review of systematic reviews evaluating the effectiveness of tendinopathy treatments. Scand.
        J Med Sci Sports. 2020; 30: 1810-1826
        • Vajapey S.
        • Ghenbot S.
        • Baria M.R.
        • et al.
        Utility of percutaneous ultrasonic tenotomy for tendinopathies: a systematic review. sports health:.
        A Multidisciplinary Approach. 2021; 13: 258-264
        • Redler L.H.
        • Thompson S.A.
        • Hsu S.H.
        • et al.
        Platelet-rich plasma therapy: a systematic literature review and evidence for clinical use.
        Phys Sportsmed. 2011; 39: 42-51
        • Engebretsen L.
        • Steffen K.
        • Alsousou J.
        • et al.
        IOC consensus paper on the use of platelet-rich plasma in sports medicine.
        Br J Sports Med. 2010; 44: 1072-1081
        • Van Schaik K.D.
        • Lee K.S.
        Orthobiologics: diagnosis and treatment of common tendinopathies.
        Semin Musculoskelet Radiol. 2021; 25: 735-744
        • Zhou Y.
        • Wang J.H.-C.
        PRP Treatment efficacy for tendinopathy: a review of basic science studies.
        Biomed Res Int. 2016; 2016: 1-8
        • Alsousou J.
        • Ali A.
        • Willett K.
        • et al.
        The role of platelet-rich plasma in tissue regeneration.
        Platelets. 2013; 24: 173-182
        • Young M.
        Stem cell applications in tendon disorders: a clinical perspective.
        Stem Cells Int. 2012; 2012: 1-10
        • da Silva Meirelles L.
        • Fontes A.M.
        • Covas D.T.
        • et al.
        Mechanisms involved in the therapeutic properties of mesenchymal stem cells.
        Cytokine Growth Factor Rev. 2009; 20: 419-427
        • Teunis T.
        • Lubberts B.
        • Reilly B.T.
        • et al.
        A systematic review and pooled analysis of the prevalence of rotator cuff disease with increasing age.
        J Shoulder Elbow Surg. 2014; 23: 1913-1921
        • Kuhn J.E.
        Exercise in the treatment of rotator cuff impingement: a systematic review and a synthesized evidence-based rehabilitation protocol.
        J Shoulder Elbow Surg. 2009; 18: 138-160
        • Hoyt C.J.
        • Jay Hoyt C.
        • Halpern A.A.
        • et al.
        Tendon ruptures associated with corticosteroid therapy.
        Plast Reconstr Surg. 1978; 62: 483
        • Boorman R.S.
        • More K.D.
        • Hollinshead R.M.
        • et al.
        What happens to patients when we do not repair their cuff tears? Five-year rotator cuff quality-of-life index outcomes following nonoperative treatment of patients with full-thickness rotator cuff tears.
        J Shoulder Elbow Surg. 2018; 27: 444-448
        • Karjalainen T.V.
        • Jain N.B.
        • Page C.M.
        • et al.
        Subacromial decompression surgery for rotator cuff disease.
        Cochrane Database Syst Rev. 2019; 1: CD005619
        • Cederqvist S.
        • Flinkkila T.
        • Sormaala M.
        • et al.
        Non-surgical and surgical treatments for rotator cuff disease: a pragmatic randomised clinical trial with 2-year follow-up after initial rehabilitation.
        Ann Rheum Dis. 2020; https://doi.org/10.1136/annrheumdis-2020–219099
        • Randelli P.S.
        • Arrigoni P.
        • Cabitza P.
        • et al.
        Autologous platelet rich plasma for arthroscopic rotator cuff repair. A pilot study. Disabil.
        Rehabil. 2008; 30: 1584-1589
        • Randelli P.
        • Arrigoni P.
        • Ragone V.
        • et al.
        Platelet rich plasma in arthroscopic rotator cuff repair: a prospective RCT study, 2-year follow-up.
        J Shoulder Elbow Surg. 2011; 20: 518-528
        • Rossi L.A.
        • Piuzzi N.
        • Giunta D.
        • et al.
        Subacromial platelet-rich plasma injections decrease pain and improve functional outcomes in patients with refractory rotator cuff tendinopathy.
        Arthroscopy. 2021; 37: 2745-2753
        • Shams A.
        • El-Sayed M.
        • Gamal O.
        • et al.
        Subacromial injection of autologous platelet-rich plasma versus corticosteroid for the treatment of symptomatic partial rotator cuff tears.
        Eur J Orthop Surg Traumatol. 2016; 26: 837-842
        • Kwong C.A.
        • Woodmass J.M.
        • Gusnowski E.M.
        • et al.
        Platelet-rich plasma in patients with partial-thickness rotator cuff tears or tendinopathy leads to significantly improved short-term pain relief and function compared with corticosteroid injection: a double-blind randomized controlled trial.
        Arthroscopy. 2021; 37: 510-517
        • A. Hamid M.S.
        • Sazlina S.G.
        Platelet-rich plasma for rotator cuff tendinopathy: a systematic review and meta-analysis.
        PLoS One. 2021; 16: e0251111
        • Thepsoparn M.
        • Thanphraisan P.
        • Tanpowpong T.
        • et al.
        Comparison of a platelet-rich plasma injection and a conventional steroid injection for pain relief and functional improvement of partial supraspinatus tears.
        Orthopaedic J Sports Med. 2021; 9 (232596712110249)
        • Kesikburun S.
        • Tan A.K.
        • Yılmaz B.
        • et al.
        Platelet-rich plasma injections in the treatment of chronic rotator cuff tendinopathy.
        Am J Sports Med. 2013; 41: 2609-2616
        • Prodromos C.C.
        • Finkle S.
        • Prodromos A.
        • et al.
        Treatment of Rotator Cuff Tears with platelet rich plasma: a prospective study with 2 year follow-up. BMC Musculoskelet.
        Disord. 2021; 22: 499
        • Gulotta L.V.
        • Kovacevic D.
        • Packer J.D.
        • et al.
        Bone Marrow–derived mesenchymal stem cells transduced with scleraxis improve rotator cuff healing in a rat model.
        Am J Sports Med. 2011; 39: 1282-1289
        • Oh J.H.
        • Chung S.W.
        • Kim S.H.
        • et al.
        2013 Neer Award: effect of the adipose-derived stem cell for the improvement of fatty degeneration and rotator cuff healing in rabbit model.
        J Shoulder Elbow Surg. 2014; 23: 445-455
        • Hernigou P.
        • Lachaniette C.H.F.
        • Delambre J.
        • et al.
        Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study.
        Int Orthop. 2014; 38: 1811-1818
        • Jo C.H.
        • Chai J.W.
        • Jeong E.C.
        • et al.
        Intratendinous injection of autologous adipose tissue-derived mesenchymal stem cells for the treatment of rotator cuff disease: a first-in-human trial.
        Stem Cells. 2018; 36: 1441-1450
        • Doran A.
        • Gresham G.A.
        • Rushton N.
        • et al.
        Tennis elbow: a clinicopathologic study of 22 cases followed for 2 years. Acta Orthop.
        Scand. 1990; 61: 535-538
        • Shiri R.
        • Viikari-Juntura E.
        Lateral and medial epicondylitis: role of occupational factors.
        Best Pract Res Clin Rheumatol. 2011; 25: 43-57
        • Bhabra G.
        • Wang A.
        • Ebert J.R.
        • et al.
        Lateral elbow tendinopathy: development of a pathophysiology-based treatment algorithm.
        Orthop J Sports Med. 2016; 4 (2325967116670635)
        • Radwan Y.A.
        • ElSobhi G.
        • Badawy W.S.
        • et al.
        Resistant tennis elbow: shock-wave therapy versus percutaneous tenotomy.
        Int Orthop. 2008; 32: 671-677
        • Kwon B.C.
        • Kim J.Y.
        • Park K.-T.
        The Nirschl procedure versus arthroscopic extensor carpi radialis brevis débridement for lateral epicondylitis.
        J Shoulder Elbow Surg. 2017; 26: 118-124
        • Dunkow P.D.
        • Jatti M.
        • Muddu B.N.
        A comparison of open and percutaneous techniques in the surgical treatment of tennis elbow.
        J Bone Joint Surg Br. 2004; 86: 701-704
        • Solheim E.
        • Hegna J.
        • Øyen J.
        • et al.
        arthroscopic treatment of lateral epicondylitis: tenotomy versus debridement.
        Arthrosc J Arthroscopic Relat Surg. 2016; 32: 578-585
        • Peerbooms J.C.
        • Sluimer J.
        • Bruijn D.J.
        • et al.
        Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial.
        Am J Sports Med. 2010; 38: 255-262
        • Kemp J.A.
        • Olson M.A.
        • Tao M.A.
        • et al.
        Platelet-rich plasma versus corticosteroid injection for the treatment of lateral epicondylitis: a systematic review of systematic reviews.
        Int J Sports Phys Ther. 2021; https://doi.org/10.26603/001c.24148
        • Thanasas C.
        • Papadimitriou G.
        • Charalambidis C.
        • et al.
        Platelet-rich plasma versus autologous whole blood for the treatment of chronic lateral elbow epicondylitis.
        Am J Sports Med. 2011; 39: 2130-2134
        • Mishra A.K.
        • Skrepnik N.V.
        • Edwards S.G.
        • et al.
        Efficacy of platelet-rich plasma for chronic tennis elbow: a double-blind, prospective, multicenter, randomized controlled trial of 230 patients.
        Am J Sports Med. 2014; 42: 463-471
        • Shim J.W.
        • Lee J.-S.
        • Park Y.-B.
        • et al.
        The effect of leucocyte concentration of platelet-rich plasma on outcomes in patients with lateral epicondylitis: a systematic review and meta-analysis.
        J Shoulder Elbow Surg. 2022; 31: 634-645
        • Muthu S.
        • Patel S.
        • Gobbur A.
        • et al.
        Platelet-rich plasma therapy ensures pain reduction in the management of lateral epicondylitis – a PRISMA-compliant network meta-analysis of randomized controlled trials.
        Expert Opin Biol Ther. 2022; 22: 1-12
        • Arirachakaran A.
        • Sukthuayat A.
        • Sisayanarane T.
        • et al.
        Platelet-rich plasma versus autologous blood versus steroid injection in lateral epicondylitis: systematic review and network meta-analysis.
        J Orthop Trauma. 2016; 17: 101-112
        • Singh A.
        • Gangwar D.
        • Singh S.
        Bone marrow injection: a novel treatment for tennis elbow.
        J Nat Sci Biol Med. 2014; 5: 389
        • Lee S.Y.
        • Kim W.
        • Lim C.
        • et al.
        Treatment of lateral epicondylosis by using allogeneic adipose-derived mesenchymal stem cells: a pilot study.
        Stem Cells. 2015; 33: 2995-3005
        • Wang A.W.
        • Bauer S.
        • Goonatillake M.
        • et al.
        Autologous tenocyte implantation, a novel treatment for partial-thickness rotator cuff tear and tendinopathy in an elite athlete.
        Case Rep. 2013; 2013 (bcr2012007899)
        • Wang A.
        • Breidahl W.
        • Mackie K.E.
        • et al.
        Autologous tenocyte injection for the treatment of severe, chronic resistant lateral epicondylitis.
        Am J Sports Med. 2013; 41: 2925-2932
        • Dakkak A.
        • Krill M.L.
        • Fogarty A.
        • et al.
        Stem cell therapy for the management of lateral elbow tendinopathy: a systematic literature review.
        Sci Sports. 2021; 36: 181-192
        • Shiri R.
        • Viikari-Juntura E.
        • Varonen H.
        • et al.
        Prevalence and determinants of lateral and medial epicondylitis: a population study.
        Am J Epidemiol. 2006; 164: 1065-1074
        • Pingel J.
        • Lu Y.
        • Fredberg U.
        • et al.
        3-D ultrastructure and collagen composition of healthy and overloaded human tendon: evidence of tenocyte and matrix buckling.
        J Anat. 2014; 224: 548-555
        • Amin N.H.
        • Kumar N.S.
        • Schickendantz M.S.
        Medial epicondylitis: evaluation and management.
        J Am Acad Orthop Surg. 2015; 23: 348-355
        • Suresh S.P.
        • Ali K.E.
        • Jones H.
        • et al.
        Medial epicondylitis: is ultrasound guided autologous blood injection an effective treatment? ∗ Commentary ∗ Commentary.
        Br J Sports Med. 2006; 40: 935-939
        • Boden A.L.
        • Scott M.T.
        • Dalwadi P.P.
        • et al.
        Platelet-rich plasma versus Tenex in the treatment of medial and lateral epicondylitis.
        J Shoulder Elbow Surg. 2019; 28: 112-119
        • Varshney A.
        • Maheshwari R.
        • Juyal A.
        • et al.
        Autologous platelet-rich plasma versus corticosteroid in the management of elbow epicondylitis: a randomized study.
        Int J Appl Basic Med Res. 2017; 7: 125-128
        • Safran M.R.
        • Graham S.M.
        Distal biceps tendon ruptures: incidence, demographics, and the effect of smoking.
        Clin Orthop Relat Res. 2002; : 275-283
        • Kelly M.P.
        • Perkinson S.G.
        • Ablove R.H.
        • et al.
        Distal biceps tendon ruptures.
        Am J Sports Med. 2015; 43: 2012-2017
        • Ramsey M.L.
        Distal biceps tendon injuries: diagnosis and management.
        J Am Acad Orthop Surg. 1999; 7: 199-207
        • Sanli I.
        • Morgan B.
        • van Tilborg F.
        • et al.
        Single injection of platelet-rich plasma (PRP) for the treatment of refractory distal biceps tendonitis: long-term results of a prospective multicenter cohort study. Knee Surg. Sports Traumatol.
        Arthrosc. 2016; 24: 2308-2312
        • Barker S.L.
        • Bell S.N.
        • Connell D.
        • et al.
        Ultrasound-guided platelet-rich plasma injection for distal biceps tendinopathy.
        Shoulder & Elbow. 2015; 7: 110-114
        • King D.
        • Yakubek G.
        • Chughtai M.
        • et al.
        Quadriceps tendinopathy: a review-part 1: epidemiology and diagnosis.
        Ann Transl Med. 2019; 7: 71
        • Vander Doelen T.
        • Jelley W.
        Non-surgical treatment of patellar tendinopathy: a systematic review of randomized controlled trials.
        J Sci Med Sport. 2020; 23: 118-124
        • Vetrano M.
        • Castorina A.
        • Vulpiani M.C.
        • et al.
        Platelet-rich plasma versus focused shock waves in the treatment of Jumper’s knee in athletes.
        Am J Sports Med. 2013; 41: 795-803
        • Lian Ø.B.
        • Engebretsen L.
        • et al.
        Prevalence of jumper’s knee among elite athletes from different sports: a cross-sectional study.
        Am J Sports Med. 2005; 33: 561-567
        • Zwerver J.
        • Bredeweg S.W.
        • Van Den Akker-Scheek I.
        Prevalence of jumper’s knee among nonelite athletes from different sports: a cross-sectional survey.
        Am J Sports Med. 2011; 39: 1984-1988
        • Sprague A.
        • Epsley S.
        • Silbernagel K.G.
        Distinguishing quadriceps tendinopathy and patellar tendinopathy: semantics or significant?.
        J Orthop Sports Phys Ther. 2019; 49: 627-630
        • Ferretti A.
        Epidemiology of jumper’s knee.
        Sports Med. 1986; 3: 289-295
        • Scott A.
        • LaPrade R.F.
        • Harmon K.G.
        • et al.
        Platelet-rich plasma for patellar tendinopathy: a randomized controlled trial of leukocyte-rich PRP or Leukocyte-Poor PRP versus saline.
        Am J Sports Med. 2019; 47: 1654-1661
        • Dragoo J.L.
        • Wasterlain A.S.
        • Braun H.J.
        • et al.
        Platelet-rich plasma as a treatment for patellar tendinopathy: a double-blind, randomized controlled trial.
        Am J Sports Med. 2014; 42: 610-618
        • Filardo G.
        • Kon E.
        • Della Villa S.
        • et al.
        Use of platelet-rich plasma for the treatment of refractory jumper’s knee.
        Int Orthopaedics. 2010; 34: 909-915
        • Wagner R.J.
        • Zach K.N.
        Platelet-rich plasma injection for quadriceps tendinopathy: a case report.
        WMJ. 2021; 120: 78-81
        • Pascual-Garrido C.
        • Rolón A.
        • Makino A.
        Treatment of chronic patellar tendinopathy with autologous bone marrow stem cells: a 5-year-followup.
        Stem Cells Int. 2012; https://doi.org/10.1155/2012/953510
        • Rodas G.
        • Soler-Rich R.
        • Rius-Tarruella J.
        • et al.
        Effect of autologous expanded bone marrow mesenchymal stem cells or leukocyte-poor platelet-rich plasma in chronic patellar tendinopathy (with gap >3 mm): preliminary outcomes after 6 months of a double-blind, randomized, prospective study.
        Am J Sports Med. 2021; 49: 1492-1504
        • Jacobson J.A.
        • Yablon C.M.
        • Henning P.T.
        • et al.
        Greater trochanteric pain syndrome: percutaneous tendon fenestration versus platelet-rich plasma injection for treatment of gluteal tendinosis.
        J Ultrasound Med. 2016; 35: 2413-2420
        • Albers I.S.
        • Zwerver J.
        • Diercks R.L.
        • et al.
        Incidence and prevalence of lower extremity tendinopathy in a Dutch general practice population: a cross sectional study. BMC Musculoskelet.
        Disord. 2016; 17
        • Fearon A.M.
        • Cook J.L.
        • Scarvell J.M.
        • et al.
        Greater trochanteric pain syndrome negatively affects work, physical activity and quality of life: a case control study.
        J Arthroplasty. 2014; 29: 383-386
        • Nuelle C.W.
        • Cook C.R.
        • Stoker A.M.
        • et al.
        In vitro toxicity of local anaesthetics and corticosteroids on supraspinatus tenocyte viability and metabolism.
        J Orthop Translat. 2017; 8: 20-24
        • Domb B.G.
        • Carreira D.S.
        Endoscopic repair of full-thickness gluteus medius Tears.
        Arthrosc Tech. 2013; 2: e77-e81
        • Lee J.J.
        • Harrison J.R.
        • Boachie-Adjei K.
        • et al.
        Platelet-rich plasma injections with needle tenotomy for gluteus medius tendinopathy: a registry study with prospective follow-up.
        Orthopaedic J Sports Med. 2016; 4: 1-7
        • Fitzpatrick J.
        • Bulsara M.K.
        • O’Donnell J.
        • et al.
        Leucocyte-rich platelet-rich plasma treatment of gluteus medius and minimus tendinopathy: a double-blind randomized controlled trial with 2-year follow-up.
        Am J Sports Med. 2019; 47: 1130-1137
        • Engebretsen A.H.
        • Myklebust G.
        • Holme I.
        • et al.
        Intrinsic risk factors for hamstring injuries among male soccer players: a prospective cohort study.
        Am J Sports Med. 2010; 38: 1147-1153
        • Gabbe B.J.
        • Bennell K.L.
        • Finch C.F.
        • et al.
        Predictors of hamstring injury at the elite level of Australian football.
        Scand J Med Sci Sports. 2006; 16: 7-13
        • Chumanov E.S.
        • Heiderscheit B.C.
        • Thelen D.G.
        The effect of speed and influence of individual muscles on hamstring mechanics during the swing phase of sprinting.
        J Biomech. 2007; 40: 3555-3562
        • Puranen J.
        • Orava S.
        The hamstring syndrome–a new gluteal sciatica.
        Ann Chir Gynaecol. 1991; 80: 212-214
        • Lempainen L.
        • Sarimo J.
        • Mattila K.
        • et al.
        Proximal hamstring tendinopathy: results of surgical management and histopathologic findings. Am.
        J Sports Med. 2009; 37: 727-734
        • Fredericson M.
        • Moore W.
        • Guillet M.
        • et al.
        High hamstring tendinopathy in runners: meeting the challenges of diagnosis, treatment, and rehabilitation.
        Phys Sportsmed. 2005; 33: 32-43
        • Zissen M.H.
        • Wallace G.
        • Stevens K.J.
        • et al.
        High hamstring tendinopathy: MRI and ultrasound imaging and therapeutic efficacy of percutaneous corticosteroid injection.
        AJR Am J Roentgenol. 2010; 195: 993-998
        • Sarimo J.
        • Lempainen L.
        • Mattila K.
        • et al.
        Complete proximal hamstring avulsions: a series of 41 patients with operative treatment.
        Am J Sports Med. 2008; 36: 1110-1115
        • Fletcher A.N.
        • Lau B.C.
        • Mather 3rd, R.C.
        Endoscopic proximal hamstring tendon repair for nonretracted tears: an anatomic approach and repair technique.
        Arthrosc Tech. 2020; 9: e483-e491
        • Belk J.W.
        • Kraeutler M.J.
        • Mei-Dan O.
        • et al.
        Return to sport after proximal hamstring tendon repair: a systematic review.
        Orthop J Sports Med. 2019; 7 (2325967119853218)
      1. Fader, R. R. et al. Platelet-rich plasma treatment improves outcomes for chronic proximal hamstring injuries in an athletic population. vol. 4 461–466 (2014).

        • Auriemma M.J.
        • Tenforde A.S.
        • Harris A.
        • et al.
        Platelet-rich plasma for treatment of chronic proximal hamstring tendinopathy.
        Regen Med. 2020; 15: 1509-1518
        • Krauss J.
        • Nugent R.
        • Bodor M.
        • et al.
        Clinical medical reviews and case reports therapeutic efficacy of platelet-rich plasma injections in treating chronic high hamstring tendinopathy.
        Clin Med. 2016; : 1-5
        • Davenport K.L.
        • Campos J.S.
        • Nguyen J.
        • et al.
        Ultrasound-guided intratendinous injections with platelet-rich plasma or autologous whole blood for treatment of proximal hamstring tendinopathy: a double-blind randomized controlled trial.
        J Ultrasound Med. 2015; 34: 1455-1463
        • Levy G.M.
        • Lucas P.
        • Hope N.
        Efficacy of a platelet-rich plasma injection for the treatment of proximal hamstring tendinopathy: a pilot study.
        J Sci Med Sport. 2019; 22: 247-252
        • Hölmich P.
        • Uhrskou P.
        • Ulnits L.
        • et al.
        Effectiveness of active physical training as treatment for long-standing adductor-related groin pain in athletes: randomised trial.
        Lancet. 1999; 353: 439-443
        • Meyers W.C.
        • Lanfranco A.
        • Castellanos A.
        Surgical management of chronic lower abdominal and groin pain in high-performance athletes.
        Curr Sports Med Rep. 2002; 1: 301-305
        • Singh J.R.
        • Roza R.
        • Bartolozzi A.R.
        Platelet rich plasma therapy in an athlete with adductor longus tendon tear.
        Univ Penn Orthop J. 2010; 20: 42-43
        • Järvinen T.A.H.
        • Kannus P.
        • Maffulli N.
        • et al.
        Achilles tendon disorders: etiology and epidemiology.
        Foot Ankle Clin. 2005; 10: 255-266
        • Li H.-Y.
        • Hua Y.-H.
        Achilles tendinopathy: current concepts about the basic science and clinical treatments.
        Biomed Res Int. 2016; 2016: 1-9
        • Zhi X.
        • Liu X.
        • Han J.
        • et al.
        Nonoperative treatment of insertional Achilles tendinopathy: a systematic review.
        J Orthop Surg Res. 2021; 16: 233
        • Patricios J.
        • Harmon K.G.
        • Drezner J.
        PRP use in sport and exercise medicine: be wary of science becoming the sham.
        Br J Sports Med. 2022; 56: 66-67
        • Nauwelaers A.-K.
        • Van Oost L.
        • Peers K.
        Evidence for the use of PRP in chronic midsubstance Achilles tendinopathy: a systematic review with meta-analysis.
        Foot Ankle Surg. 2021; 27: 486-495
        • Chen J.
        • Wan Y.
        • Jiang H.
        The effect of platelet-rich plasma injection on chronic Achilles tendinopathy and acute Achilles tendon rupture.
        Platelets. 2021; 33: 1-11
        • Kearney R.S.
        • Ji C.
        • Warwick J.
        • et al.
        Effect of platelet-rich plasma injection vs sham injection on tendon dysfunction in patients with chronic midportion achilles tendinopathy.
        JAMA. 2021; 326: 137
        • Boesen A.P.
        • Hansen R.
        • Boesen M.I.
        • et al.
        Effect of high-volume injection, platelet-rich plasma, and sham treatment in chronic midportion achilles tendinopathy: a randomized double-blinded prospective study.
        Am J Sports Med. 2017; 45: 2034-2043
        • Erroi D.
        Conservative treatment for Insertional Achilles Tendinopathy: platelet-rich plasma and focused shock waves. A retrospective study. Muscle,.
        Ligaments Tendons J. 2017; 7: 98
        • Usuelli F.G.
        • Grassi M.
        • Maccario C.
        • et al.
        Intratendinous adipose-derived stromal vascular fraction (SVF) injection provides a safe, efficacious treatment for Achilles tendinopathy: results of a randomized controlled clinical trial at a 6-month follow-up.
        Knee Surg Sports Traumatol Arthrosc. 2018; 26: 2000-2010
        • Albano D.
        • Messina C.
        • Usuelli F.G.
        • et al.
        Magnetic resonance and ultrasound in achilles tendinopathy: predictive role and response assessment to platelet-rich plasma and adipose-derived stromal vascular fraction injection.
        Eur J Radiol. 2017; 95: 130-135
        • Thueakthong W.
        • de Cesar Netto C.
        • Garnjanagoonchorn A.
        • et al.
        Outcomes of iliac crest bone marrow aspirate injection for the treatment of recalcitrant Achilles tendinopathy.
        Int Orthop. 2021; 45: 2423-2428
        • Rosenbaum A.J.
        • DiPreta J.A.
        • Misener D.
        Plantar heel pain.
        Med Clin North Am. 2014; 98: 339-352
        • Luffy L.
        • Grosel J.
        • Thomas R.
        • et al.
        Plantar fasciitis: a review of treatments.
        J Am Acad Physician Assist. 2018; 31: 20-24
        • Maffulli N.
        • Wong J.
        • Almekinders L.C.
        Types and epidemiology of tendinopathy.
        Clin Sports Med. 2003; 22: 675-692
        • Malahias M.-A.
        • Cantiller E.B.
        • Kadu V.V.
        • et al.
        The clinical outcome of endoscopic plantar fascia release: a current concept review.
        Foot Ankle Surg. 2020; 26: 19-24
        • Jain K.
        • Murphy P.N.
        • Clough T.M.
        Platelet rich plasma versus corticosteroid injection for plantar fasciitis: a comparative study.
        The Foot. 2015; 25: 235-237
        • Monto R.R.
        Platelet-rich plasma efficacy versus corticosteroid injection treatment for chronic severe plantar fasciitis.
        Foot Ankle Int. 2014; 35: 313-318
        • Peerbooms J.C.
        • Lodder P.
        • den Oudsten B.L.
        • et al.
        Positive effect of platelet-rich plasma on pain in plantar fasciitis: a double-blind multicenter randomized controlled trial.
        Am J Sports Med. 2019; 47: 3238-3246
        • Jiménez-Pérez A.E.
        • Gonzalez-Arabio D.
        • Diaz A.S.
        • et al.
        Clinical and imaging effects of corticosteroids and platelet-rich plasma for the treatment of chronic plantar fasciitis: a comparative non randomized prospective study.
        Foot Ankle Surg. 2019; 25: 354-360
        • Fei X.
        • Lang L.
        • Lingjiao H.
        • et al.
        Platelet-rich plasma has better mid-term clinical results than traditional steroid injection for plantar fasciitis: a systematic review and meta-analysis.
        Orthop Traumatol Surg Res. 2021; 107: 103007
        • Hohmann E.
        • Tetsworth K.
        • Glatt V.
        Platelet-rich plasma versus corticosteroids for the treatment of plantar fasciitis: a systematic review and meta-analysis.
        Am J Sports Med. 2021; 49: 1381-1393