Advertisement

Medical Concerns in Orthobiologics Procedures

  • Peter C. Yeh
    Affiliations
    Department of Physical Medicine and Rehabilitation, Vanderbilt University, Nashville, TN, USA

    Vanderbilt Stallworth Rehabilitation Hospital, 2201 Children’s Way, Suite 1318, Nashville, TN 37212, USA
    Search for articles by this author
  • Prathap Jayaram
    Correspondence
    Corresponding author.
    Affiliations
    Department of Orthopedics, Emory University, Atlanta, GA, USA

    Department of Rehabilitation Medicine, Emory University, Emory Sports Medicine Complex, 1968 Hawks Lane, Brookhaven, GA 30329, USA
    Search for articles by this author
Published:October 17, 2022DOI:https://doi.org/10.1016/j.pmr.2022.08.006

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.

      Content published before 2002 is available via pay-per-view purchase only.

      Subscribe:

      Subscribe to Physical Medicine and Rehabilitation Clinics
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Everts P.
        • Onishi K.
        • Jayaram P.
        • et al.
        Platelet-rich plasma: new performance understandings and therapeutic considerations in 2020.
        Int J Mol Sci. 2020; 21: 7794
        • Feisst V.
        • Meidinger S.
        • Locke M.B.
        Stem cells and cloning: advances and applications dovepress from bench to bedside: use of human adipose-derived stem cells.
        Stem Cells Cloning Adv Appl. 2015; 8: 149-162
        • Dhillon R.S.
        • Schwarz E.M.
        • Maloney M.D.
        Platelet-rich plasma therapy - future or trend?.
        Arthritis Res Ther. 2010; 14: 219
        • Ialongo C.
        • Bernardini S.
        Special issue: responsible writing in science Phlebotomy, a bridge between laboratory and patient.
        Biochem Med. 2016; 26: 17-33
        • Hjortholm N.
        • Jaddini E.
        • Hałaburda K.
        • et al.
        Strategies of pain reduction during the bone marrow biopsy.
        Ann Hematol. 2013; 92: 145-149
        • Malanga G.
        • Abdelshahed D.
        • Jayaram P.
        Orthobiologic interventions using ultrasound guidance.
        Phys Med Rehabil Clin N Am. 2016; 27: 717-731
        • Le A.D.K.
        • Enweze L.
        • DeBaun M.R.
        • et al.
        Current clinical recommendations for use of platelet-rich plasma.
        Curr Rev Musculoskelet Med. 2018; 11: 624-634
        • dos Santos R.G.
        • Santos G.S.
        • Alkass N.
        • et al.
        The regenerative mechanisms of platelet-rich plasma: a review.
        Cytokine. 2021; 144: 155560
        • Andia I.
        • Maffulli N.
        A contemporary view of platelet-rich plasma therapies: moving toward refined clinical protocols and precise indications.
        Regen Med. 2018; 13: 717-728
        • Kalyam K.
        • Kavoussi S.C.
        • Ehrlich M.
        • et al.
        Irreversible blindness following periocular autologous platelet-rich plasma skin rejuvenation treatment.
        Ophthal Plast Reconstr Surg. 2017; 33: S12-S16
        • Di Martino A.
        • Boffa A.
        • Andriolo L.
        • et al.
        Leukocyte-rich versus leukocyte-poor platelet-rich plasma for the treatment of knee osteoarthritis: a double-blind randomized trial.
        Am J Sports Med. 2022; (3635465211064303)
        • Bain B.J.
        Morbidity associated with bone marrow aspiration and trephine biopsy - A review of UK data for 2004.
        Haematologica. 2006; 91: 1293-1294
        • Cole B.J.
        • Gilat R.
        • DiFiori J.
        • et al.
        The 2020 NBA orthobiologics consensus statement.
        Orthop J Sport Med. 2021; 9https://doi.org/10.1177/23259671211002296
        • Bowen J.E.
        Technical issues in harvesting and concentrating stem cells (bone marrow and adipose).
        PM R. 2015; 7: S8-S18
        • Hernigou J.
        • Picard L.
        • Alves A.
        • et al.
        Understanding bone safety zones during bone marrow aspiration from the iliac crest: the sector rule.
        Int Orthop. 2014; 38: 2377-2284
        • Schroeder A.
        • Rubin J.P.
        • Kokai L.
        • et al.
        Use of adipose-derived orthobiologics for musculoskeletal injuries: a narrative review.
        PM R. 2020; 12: 805-816
        • Maione L.
        • Vinci V.
        • Klinger M.
        • et al.
        Autologous fat graft by needle: analysis of complications after 1000 patients.
        Ann Plast Surg. 2015; 74: 277-280
        • Alsousou J.
        • Thompson M.
        • Hulley P.
        • et al.
        The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery: a review of the literature.
        J Bone Joint Surg Br. 2009; 91: 987-996
        • Cmolik B.L.
        • Spero J.A.
        • Magovern G.J.
        • et al.
        Redo cardiac surgery: late bleeding complications from topical thrombin- induced factor V deficiency.
        J Thorac Cardiovasc Surg. 1993; 105: 222-227
        • Sampson S.
        • Botto-van Bemden A.
        • Aufiero D.
        Autologous bone marrow concentrate: review and application of a novel intra-articular orthobiologic for cartilage disease.
        Phys Sportsmed. 2013; 41: 7-18
        • Freese K.E.
        • Kokai L.
        • Edwards R.P.
        • et al.
        Adipose-derived stems cells and their role in human cancer development, growth, progression, and metastasis: a systematic review.
        Cancer Res. 2015; 75: 1161-1168
        • Hernigou P.
        • Homma Y.
        • Flouzat-Lachaniette C.H.
        • et al.
        Cancer risk is not increased in patients treated for orthopaedic diseases with autologous bone marrow cell concentrate.
        J Bone Joint Surg Am. 2013; 95: 2215-2221
        • Wakitani S.
        • Okabe T.
        • Horibe S.
        • et al.
        Safety of autologous bone marrow-derived mesenchymal stem cell transplantation for cartilage repair in 41 patients with 45 joints followed for up to 11 years and 5 months.
        J Tissue Eng Regen Med. 2011; 5: 146-150
        • Pak J.
        • Chang J.J.
        • Lee J.H.
        • et al.
        Safety reporting on implantation of autologous adipose tissue-derived stem cells with platelet-rich plasma into human articular joints.
        BMC Musculoskelet Disord. 2013; 1: 337
        • Centeno C.
        • Schultz J.
        • Cheever M.
        • et al.
        Safety and complications reporting on the re-implantation of culture-expanded mesenchymal stem cells using autologous platelet lysate technique.
        Curr Stem Cell Res Ther. 2010; 5: 81-93
        • Centeno C.J.
        • Al-Sayegh H.
        • Freeman M.D.
        • et al.
        A multi-center analysis of adverse events among two thousand, three hundred and seventy two adult patients undergoing adult autologous stem cell therapy for orthopaedic conditions.
        Int Orthop. 2016; 40: 1755-1765
        • Song Y.
        • Du H.
        • Dai C.
        • et al.
        Human adipose-derived mesenchymal stem cells for osteoarthritis: a pilot study with long-term follow-up and repeated injections.
        Regen Med. 2018; 13: 295-307
        • Kuah D.
        • Sivell S.
        • Longworth T.
        • et al.
        Safety, tolerability and efficacy of intra-articular Progenza in knee osteoarthritis: a randomized double-blind placebo-controlled single ascending dose study.
        J Transl Med. 2018; 16: 49
        • Schneider B.J.
        • Hunt C.
        • Conger A.
        • et al.
        The effectiveness of intradiscal biologic treatments for discogenic low back pain: a systematic review.
        Spine J. 2022; 22: 226-237
        • Beatty N.R.
        • Lutz C.
        • Boachie-Adjei K.
        • et al.
        Spondylodiscitis due to Cutibacterium acnes following lumbosacral intradiscal biologic therapy: a case report.
        Regen Med. 2019; 14: 823-829
        • Fraser R.D.
        • Osti O.L.
        • Vernon-Roberts B.
        Discitis after discography.
        J Bone Joint Surg Br. 1987; 69: 26-35
        • Jerome M.A.
        • Lutz C.
        • Lutz G.E.
        Risks of intradiscal orthobiologic injections: a review of the literature and case series presentation.
        Int J Spine Surg. 2021; 15: 26-39
        • Frey C.
        • Yeh P.C.
        • Jayaram P.
        Effects of antiplatelet and nonsteroidal anti-inflammatory medications on platelet-rich plasma: a systematic review.
        Orthop J Sport Med. 2020; 8https://doi.org/10.1177/2325967120912841
        • Jayaram P.
        • Yeh P.
        • Patel S.J.
        • et al.
        Effects of aspirin on growth factor release from freshly isolated leukocyte-rich platelet-rich plasma in healthy men: a prospective fixed-sequence controlled laboratory study.
        Am J Sports Med. 2019; 47: 1223-1229
        • Mannava S.
        • Whitney K.E.
        • Kennedy M.I.
        • et al.
        The Influence of naproxen on biological factors in leukocyte-rich platelet-rich plasma: a prospective comparative study.
        Arthrosc - J Arthrosc Relat Surg. 2019; 35: 201-210
        • Schippinger G.
        • Prüller F.
        • Divjak M.
        • et al.
        Autologous platelet-rich plasma preparations: influence of nonsteroidal anti-inflammatory drugs on platelet function.
        Orthop J Sport Med. 2015; 3https://doi.org/10.1177/2325967115588896
        • Chu C.R.
        • Rodeo S.
        • Bhutani N.
        • et al.
        Optimizing clinical use of biologics in orthopaedic surgery: consensus recommendations from the 2018 AAOS/NIH U-13 conference.
        J Am Acad Orthop Surg. 2019; 27: e50-e63