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Contributors
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iii-vii
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Contents
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ix-xiii
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Forthcoming Issues
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xiv
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Advancing Neuromuscular Medicine Through Integration, Translation, and Collaboration
12 December 2011
I was quite honored a few years back when I was invited by my friend and colleague, Dr Rick Lieber, to become a member of the external advisory board for his National Institutes of Health investigator...
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Gregory T. Carter
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xv-xvii
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Use of Skeletal Muscle MRI in Diagnosis and Monitoring Disease Progression in Duchenne Muscular Dystrophy
16 December 2011
Studies have shown promise in using various approaches of magnetic resonance imaging (MRI) and magnetic resonance spectroscopy to evaluate skeletal muscle involvement in Duchenne muscular dystrophy. H...
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Erika L. Finanger,
Barry Russman,
Sean C. Forbes,
William D. Rooney,
Glenn A. Walter,
Krista Vandenborne
et al.
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1-10
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Techniques in Assessing Fatigue in Neuromuscular Diseases
12 December 2011
Fatigue is common in neuromuscular disease and it may affect quality of life; however, it has not been adequately studied. We can approach fatigue in neuromuscular diseases systematically. Questionnai...
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Jau-Shin Lou
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11-22
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The Utility of Electromyography and Mechanomyography for Assessing Neuromuscular Function: A Noninvasive Approach
This article introduces the utility of electromyography (EMG) and mechanomyography (MMG) for the assessment of neuromuscular function, and discusses the interpretation of the EMG and MMG signals for v...
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Moh H. Malek,
Jared W. Coburn
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23-32
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Novel Concepts Integrated in Neuromuscular Assessments for Surgical Restoration of Arm and Hand Function in Tetraplegia
16 December 2011
Surgical restoration of key functions of the upper extremity has tremendous potential to increase autonomy, mobility, and self-esteem by resuming critical abilities in patients with tetraplegia. New s...
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Jan Fridén,
Andreas Gohritz
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33-50
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The Effects of Active and Passive Stretching on Muscle Length
05 December 2011
Active stretch is necessary for regulating muscle fiber length (ie, the number of series sarcomeres). Elevated cytoplasmic calcium is the proposed component of contractile activity required to activat...
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Danny A. Riley,
J.M. Van Dyke
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51-57
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Hypohomocysteinemia: A Potentially Treatable Cause of Peripheral Neuropathology?
16 December 2011
Perturbations of homocysteine metabolism are associated with increased risk for cardiovascular disease, stroke, dementia, and depression, among other major diseases. To assess the relationship between...
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Clark E. Cullen,
Gregory T. Carter,
Michael D. Weiss,
Peter A. Grant,
David Scott Saperstein
et al.
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59-65
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Regional and Whole-Body Dual-Energy X-Ray Absorptiometry to Guide Treatment and Monitor Disease Progression in Neuromuscular Disease
12 December 2011
Dual-energy x-ray absorptiometry (DEXA) is a safe, noninvasive, inexpensive tool for managing patients with neuromuscular diseases. Regional and whole-body DEXA can be used to guide clinical treatment...
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Andrew J. Skalsky,
Jay J. Han,
Richard T. Abresch,
Craig M. McDonald
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67-73
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Establishing Clinical End Points of Respiratory Function in Large Animals for Clinical Translation
16 December 2011
Respiratory dysfunction due progressive weakness of the respiratory muscles, particularly the diaphragm, is a major cause of death in the neuromuscular disease (NMD) X-linked myotubular myopathy (XLMT...
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Melissa A. Goddard,
Erin L. Mitchell,
Barbara K. Smith,
Martin K. Childers
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75-94
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New Opportunities and Novel Paradigms to Support Neuromuscular Research
This article provides an overview of the structure and function of the National Skeletal Muscle Research Center (NSMRC) at the University of California, San Diego, which is one of the 7 research cente...
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Richard Lieber,
Samuel Ward,
Lawrence Frank,
Simon Schenk
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95-105
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Skeletal Muscle Edema in Muscular Dystrophy: Clinical and Diagnostic Implications
16 December 2011
Muscle degeneration in muscular dystrophies often includes a period of edema before fatty replacement of muscle tissue. Magnetic resonance imaging (MRI) has been used successfully to characterize musc...
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Sandra L. Poliachik,
Seth D. Friedman,
Gregory T. Carter,
Shawn E. Parnell,
Dennis W. Shaw
et al.
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107-122
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Cardiac MRI in Muscular Dystrophy: An Overview and Future Directions
Cardiac complications are a common feature of many muscular dystrophies. Although many modalities (eg, ultrasound) provide exceptional efficacy for early diagnosis, repeated monitoring, and therapeuti...
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Randolph K. Otto,
Mark R. Ferguson,
Seth D. Friedman
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123-132
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Neuromuscular Ultrasonography: Quantifying Muscle and Nerve Measurements
12 December 2011
Neuromuscular ultrasonography can be used both descriptively and quantitatively in the evaluation of patients with neuromuscular disorders. This article reviews the quantitative use of this technology...
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David Mayans,
Michael S. Cartwright,
Francis O. Walker
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133-148
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The Paradox of Muscle Hypertrophy in Muscular Dystrophy
Mutations in the dystrophin gene cause Duchenne and Becker muscular dystrophy in humans and syndromes in mice, dogs, and cats. Affected humans and dogs have progressive disease that leads primarily to...
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Joe N. Kornegay,
Martin K. Childers,
Daniel J. Bogan,
Janet R. Bogan,
Peter Nghiem,
Jiahui Wang,
Zheng Fan,
James F. Howard,
Scott J. Schatzberg,
Jennifer L. Dow,
Robert W. Grange,
Martin A. Styner,
Eric P. Hoffman,
Kathryn R. Wagner
et al.
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149-172
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Exercise Testing in Metabolic Myopathies
12 December 2011
Metabolic myopathies are a group of genetic disorders specifically affecting glucose/glycogen, lipid, and mitochondrial metabolism. The main metabolic myopathies that are evaluated in this article are...
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Mark Tarnopolsky
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173-186
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Nutrition Strategies to Improve Physical Capabilities in Duchenne Muscular Dystrophy
15 December 2011
There is no current cure for Duchenne muscular dystrophy (DMD), and palliative and prophylactic interventions to improve the quality of life of patients remain limited, with the exception of corticost...
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J. Davoodi,
C.D. Markert,
K.A. Voelker,
S.M. Hutson,
Robert W. Grange
et al.
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187-199
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Aging of Human Muscle: Understanding Sarcopenia at the Single Muscle Cell Level
15 December 2011
The loss of muscle mass with age, also known as sarcopenia, is a major scientific and public health problem. Muscle atrophy is associated with the loss of functional capacity and poor health outcomes ...
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Walter R. Frontera,
Ana Rodriguez Zayas,
Natividad Rodriguez
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201-207
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Index
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209-220
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